Peptest - Pepsin Detection Kit (Generation 1)

Peptest: The Globally Trusted, Non-Invasive Solution for Objective Reflux Testing

Peptest is a UK-origin, clinically validated diagnostic test that has been trusted for over 20 years and is used in more than 50 countries worldwide. It offers a non-invasive, rapid, and objective method to detect pepsin in saliva—a reliable biomarker for gastroesophageal reflux disease (GERD) and laryngopharyngeal reflux (LPR). Ideal for patients unable to tolerate invasive exams or those requiring quick screening, Peptest helps prevent overtreatment and unnecessary endoscopic procedures.

Why Choose Peptest?

✅ Non-Invasive & Patient-Friendly

Only a simple saliva sample is required—no tubes, no endoscopy. This greatly improves patient comfort and compliance, making it suitable for children, the elderly, and sensitive patients.

✅ Fast & Objective

The test can be performed during a clinic visit, with results available in just 15 minutes. It provides clinicians with objective biomarker evidence to support diagnosis and guide treatment, reducing reliance on subjective symptom reporting.

✅ Clinically Endorsed

Peptest is recommended in the 2023 Chinese GERD Diagnosis and Treatment Guidelines and the 2022 Chinese Expert Consensus on LPR Diagnosis and Management as an objective, non-invasive tool for reflux disease assessment.

✅ High Concordance with Gold Standard

Peptest shows 96.70% concordance with 24-hour MII-pH monitoring in detecting pathological reflux, and offers superior sensitivity for non-erosive reflux disease (NERD), addressing the limitations of endoscopy.

Peptest vs. Traditional 24-hour pH-Impedance Monitoring

The table below clearly compares Peptest with the traditional invasive gold standard, highlighting key clinical advantages:

Unlike invasive pH monitoring, Peptest offers a 96.7% concordance rate with zero discomfort.

Clinical Value & Applications

• Aids GERD Diagnosis – Complements symptom surveys and PPI trials, especially in endoscopy-negative NERD patients.
• Evaluates LPR – Provides ENT specialists with an objective diagnostic tool within the LPR management pathway.
• Reduces Overtreatment – Helps identify non-reflux symptoms before starting PPI therapy, avoiding unnecessary long-term acid suppression.
• Monitors Treatment Response – Repeat testing offers objective tracking of reflux control during therapy.

With its non-invasive nature, speed, and objectivity, Peptest is reshaping the diagnostic pathway for reflux diseases—offering a patient-friendly and clinically effective choice for providers worldwide.

❓FAQ

Q1：How does Peptest work? What is the principle behind it?

A1：Peptest detects the presence of pepsin in your saliva sample. Pepsin is a digestive enzyme produced only in the stomach. Its presence in saliva is an objective biomarker that gastric contents have refluxed into the esophagus or throat. This offers a non‑invasive and sensitive diagnostic method.

Q2：Do I need to stop taking any medications or drinking alkaline water before taking Peptest?

A2：Yes. Alkaline water (pH ≥8.8) can denature pepsin in vitro, which may affect test accuracy. We recommend avoiding alkaline water for 48 hours before sample collection. For medications, especially PPIs or antacids, please consult your doctor before testing, as they may influence reflux frequency and pepsin detection.